Gram Negative Bacteria

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Communicable and Noncommunicable Diseases

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Natural transformation

Constitutes a major gene transfer mechanism in the prokaryotes

Researchers found the integration of foreign DNA into the genome of the Gram-negative Acinetobacter sp. BD413 during transformation.

The active uptake of cellular DNA

The Mechanism & Function of Natural Competence

Gram Negative bacteria take up DNA in two stages :

DNA translocation (across the inner membrane)

DNA uptake (across the outer membrane)

Gram Negative Bacteria

Research

NIAID-funded researchers are exploring these related to Gram negative bacteria and the diseases they cause.

Researchers are unraveling the molecular mechanisms of drug resistance

to identify novel strategies to combat these pathogens

New drugs to combat Gram negative bacteria infections are needed.

Prevention

Vaccines are not available for most healthcare- associated caused by Gram negative bacteria.

To reduce it, hand washing and having healthcare workers wear gloves

Many infections occur through cross contamination between people.

Characteristics

Thin peptidoglycan

High Lypopolysaccharides

Appear pinkish or red

Treatment

For example, the unique nature of their cell wall makes them resistant to several antibiotics

Can be difficult because of several unique features of this bacteria

Transmission

This can lead to pneumonia and such infections of the :

urinary tract

joints

bones

bloodstream

Bacteria enter the body through :

wounds

ventilators

urinary